Pleural biopsy is performed to make a diagnosis in order to treat an underlying pulmonary or pleural condition. Typically, the diagnosis is unknown and obtaining a biopsy allows the pathologist sufficient lung tissue to perform tests and analysis to make a definitive diagnosis which aids the treating physician immensely. Historically, the pleural biopsy was performed with an open incision. Today, this procedure is performed minimally invasively using a video assisted approach, allowing patients to be discharged one to two days after surgery.